Anti-Obesity Effects of Probiotics: Efficacy, Mechanisms, and Challenges in Implementation

Topic : 

Anti-Obesity Effects of Probiotics: Efficacy, Mechanisms, and Challenges in Implementation

Summary : 

Gut microbiota dysbiosis contributes to the development of obesity-related comorbidities. The microbiota-mediated production of specific short chain fatty acids (i.e., butyrate or propionate), incretins (GLP-1) and neurotransmitters (such as GABA and serotonin) are crucial in the regulation of food intake regulation, energy balance, and metabolism. A number of probiotics (i.e., several strains of lactic acid bacteria) have been demonstrated to mitigate diet-induced obesity in rodents. One of the mechanisms is the amelioration of gut microbiota composition and function and the improvement of gut permeability. Also, inactivated postbiotics (i.e.,  Akkermansia muciniphila WST01, Pediococcus pentosaceus LP28, Bifidobacterium animalis subsp. lactis CECT 8145, Lactobacillus amylovorus CP1563) can improve adiposity-related biomarkers in humans with obesity.

Prof. Fermin Milagro, from the Center for Nutrition Research of the University of Navarra, will discuss the mechanisms of action (bacterial metabolites, exopolysaccharides, outer membrane proteins, microRNAs, extracellular vesicles,…) and present recent results from his group.