ISM Best Poster 2024 (2): Indoxyl Sulfate's Role in Dyslipidemia and Cholesterol Gene Expression
We are pleased to announce that Mateusz Szudzik from the Medical University of Warsaw, Poland, has won the Best Poster Presentation Award (2) at the Targeting Microbiota 2024 Conference.
Award Winning Poster: Indoxyl Sulfate, Gut Microbiome-Derived Uremic Toxin, Couse Dyslipidemia and Alter Gene Expression Related to Cholesterol in the Liver of Rats
Their study investigates indoxyl sulfate (IS), a gut microbiome-derived uremic toxin, and its impact on lipid metabolism in rats. Findings reveal that IS increases total cholesterol, LDL, and triglycerides levels while altering key gene expressions in the liver, suggesting IS as a potential therapeutic target for hyperlipidemia.
Dr. Szudzik stated to the ISM "I am focused on studying the effects of bacterial metabolites—such as trimethylamines, indoles, and short-chain fatty acids—on the development of cardiometabolic diseases. My particular interest lies in how these microbial metabolites regulate cholesterol metabolism, potentially influencing cholesterol homeostasis and contributing to the onset of diseases associated with hypercholesterolemia. By exploring the interactions between bacterial metabolites and host metabolic pathways, my research aims to uncover novel mechanisms that link gut microbiota activity to the progression of cardiometabolic disorders".
