Crosstalk between Gut Microbiota, Innate Immune Cells and Endocrine Cells in the Pancreas Regulates Autoimmune Diabetes

Dr. Julien Diana from Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France will present his study entitled "Crosstalk between Gut Microbiota, Innate Immune Cells and Endocrine Cells in the Pancreas Regulates Autoimmune Diabetes" during the Targeting Microbiota 2018 Congress, which will be held in Porto, in October 28-30, 2018.

In his presentation, Dr. Diana will highlight: "The gut microbiota is essential for the normal function of the gut immune system. However how the gut microbiota prevents autoimmunity in distant organs remains poorly defined. Our group recently described that the gut microbiota controls the production of antimicrobial peptides (AMPs) by the pancreatic endocrine cells. Importantly, owing to their immunoregulatory properties, AMPs are critical to maintain the immune tolerance in the pancreas. In the NOD mice, a mouse model of autoimmune diabetes, we demonstrated that dysbiosis leads to a defective production of AMPs in the pancreas and to the development of the disease. Our findings reveal a novel interplay between the gut microbiota, the endocrine cells and the immune system that contributes in preventing autoimmune diabetes.”

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