New Evidence Links Gut Bacteria and Neurodegenerative Conditions
A new study reports on an association between specific gut bacteria species and the manifestation of neurodegenerative disorders, published by Alyssa C.Walker and al.
Worms colonized by a non- pathogenic control E. coli. Credit: University of Florida
According to recent studies, protein conformational diseases are characterized by misfolding and toxic aggregation of metastable proteins, often culminating in neurodegeneration. Enteric bacteria influence the pathogenesis of neurodegenerative diseases; however, the complexity of the human microbiome hinders our understanding of how individual microbes influence these diseases.
In conclusion, Protein conformational diseases are one of the leading causes of geriatric death and disability, worldwide. Individuals suffering from these ailments are limited to palliative care, as there are no cures or effective treatments. Correlational evidence suggests that the human gut microbiota is a culprit, but the effect of individual bacteria remains elusive, in part, due to the complexity of the microbiome. A single-bacterium approach can help to deconvolute the complexity of the microbiome and reveal the effect of individual bacterial species on organismal proteostasis.
DOI: https://doi.org/10.1371/journal.ppat.1009510
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