The role of microbiota in Graft-versus-Host Disease (GvHD) and complications of allogeneic stem cell transplantation

The gut microbiota seem to play a central role in the outcome of patients undergoing allogeneic stem cell transplantation. During the course of allogeneic stem cell transplantation a loss of intestinal microbiota diversity and a shift toward an enteropathogeneic flora were observed, which were aggravated in individuals with systemic broad-spectrum antibiotic treatment and patients suffering from acute gastrointestinal GvHD. Particularly commensal bacteria seem to be crucial for the maintenanace of immunological homeostasis and intestinal epithelial integrity and therefore contribute to the success of allogeneic stem cell transplantation.

During Targeting Microbiota World Congress 2017, Dr Daniela Weber from Regensburg Universitätsklinikum, Germany will highlight the role of microbiota in Graft-versus-Host Disease (GvHD) and complications of allogeneic stem cell transplantation.

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