Gut Brain Axis & Depression: Startegic Role of Dietary Proline Exposed

José Manuel Fernández RealThe ISM is pleased to welcome Prof. José Manuel Fernández-Real, Universitat de Girona, Spain join Targeting Microbiota 2024 this October.

Prof. Fernández-Real will present a talk on "Gut Brain Axis & Depression: Startegic Role of Dietary Proline Exposed". 

Key Points:

High proline consumption emerged as the primary dietary factor significantly impacting depression. Analysis of whole-brain dynamics unveiled disruptions in the rich club network, correlating with depression and circulating proline levels. 

Notably, proline supplementation in mice exacerbated depressive symptoms, concomitant with microbial translocation. Human microbiota transplantation in mice induced an emotionally impaired phenotype, accompanied by alterations in GABA-, proline-, and extracellular matrix-related genes in the prefrontal cortex. 

Furthermore, interventions such as RNAi-mediated knockdown of proline and GABA transporters in Drosophila, and mono-association with L. plantarum, a prolific GABA producer, demonstrated protective effects against depression-like states. 

These findings underscore the potential of microbiome modulation and dietary proline targeting as promising avenues for effective depression treatment.

About José Manuel Fernández-Real

Dr. José Manuel Fernández-Real, an endocrinologist and researcher at the Girona Biomedical Research Institute, holds degrees in Medicine and a Ph.D. from the University of Barcelona, Spain. As a member of the CIBERobn Steering Committee, focusing on Obesity Research, he has contributed significantly to the field with over 500 publications, earning an impressive H index of 97 and over 37,500 citations on Google Scholar. Leading 29 National and International Projects, holding 12 patents, and supervising 14 doctoral theses, he has played pivotal roles in various research endeavors, including coordinating the European ThinkGut project. Renowned globally, he ranks among the top 40 most cited authors in Endocrinology and within the top 1% across all scientific disciplines. Over the past 5 years, his research has primarily explored the microbiota's role in metabolic disorders and cognition, with notable findings linking microbiome signatures to conditions like fatty liver and obesity-related cognitive issues. His latest work focuses on how alterations in proline metabolism impact depression through changes in the gut microbiome.

Targeting Microbiota 2024 Speakers Line-up.

International Society of Microbiota
Targeting Microbiota 2024 Conference
October 14-15, 2024 - Malta
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