The signature of Parkinson found in gut Microbiota: a PERFECT door open for PD prevention

 waked up man lying bed turning off alarm clock morn min

News Release, International Society of Microbiota, France – May 8, 2023

A recent study by Yun Kwok Wing and research team from The Chinese University of Hong Kong, published in Nature Communications, suggested that Parkinson Disease (PD) like gut dysbiosis occurs at the prodromal stages of PD, among patients with video-polysomnography diagnosed REM sleep behavior disorder and their first-degree relatives.

The microbiota-gut-brain axis has been suggested to play an important role in Parkinson’s disease. The research team performed a cross-sectional study to profile gut microbiota across early PD, REM sleep behavior disorder (RBD), first-degree relatives of RBD (RBD-FDR), and healthy controls, which could reflect the gut-brain staging model of PD.

They showed that gut microbiota compositions are significantly altered in early PD and RBD compared with control and RBD-FDR. Depletion of butyrate-producing bacteria and enrichment of pro-inflammatory Collinsella have already emerged in RBD and RBD-FDR after controlling potential confounders including antidepressants, osmotic laxatives, and bowel movement frequency.

Random forest modelling identifies 12 microbial markers that are effective to distinguish RBD from control. These findings suggest that PD-like gut dysbiosis occurs at the prodromal stages of PD when RBD develops and starts to emerge in the younger RBD-FDR subjects.

The study will have etiological and diagnostic implications.

Marvin Edeas, Institut Cochin, INSERM U1016, Université de Paris and founder of ISM, said: "The results of Yun Kwok Wing and colleagues are crucial, first, for early prediction of PD based on this signature, and second, for finding therapeutic strategies to promote butyrate-producing bacteria at a very early stage. The other important question of this study is what is the cause or causes of this microbiota dysbosis".

 Article DOI.

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