New Clinical Trial Reveals Lactiplantibacillus plantarum P9 Probiotics as Effective Treatment for Chronic Constipation
Schematic diagram showing the proposed role of Lactiplantibacillus plantarum P9 (P9)-associated host gut microbiota/metabolomic changes in relieving constipation. CSBMs, SBMs, and WO represent complete spontaneous bowel movements, spontaneous bowel movements, and worries and concerns, respectively. Photo credit: Teng Ma et al.: https://doi.org/10.1016/j.phrs.2023.106755.
A recent randomized clinical trial was conducted by several teams in China, in order to examine the effect of Lactiplantibacillus plantarum P9 probiotics on defecation and quality of life of individuals with chronic constipation. The study was conducted over a period of 42 days and involved 163 patients diagnosed with chronic constipation.
The study found that Lactiplantibacillus plantarum P9 probiotics significantly improved the weekly mean frequency of complete spontaneous bowel movements (CSBMs) and spontaneous bowel movements (SBMs) and reduced the level of worries and concerns. The reseacrhers also found that the Lactiplantibacillus plantarum P9 group was significantly enriched in potentially beneficial bacteria compared to the placebo group.
This study provides evidence that Lactiplantibacillus plantarum P9 probiotics can be an effective treatment for chronic constipation. The findings of this study could be used to inform public health policies aimed at improving the quality of life of individuals with chronic constipation.
International Society of Microbiota
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